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Home >> Service >> TARGATT™ Fast & Site-Specific Transgenic Mice >> TARGATT™ Knock-in Mice Service >> TARGATT™ Fast & Site-Specific Knockin Mice Service

TARGATT™ Fast & Site-Specific Knockin Mice Service

 Do you need a transgenic / knock-in mouse model? Applied StemCell can create site-specific knockin mice for you with a turnaround time as fast as 3 months.

Using our novel TARGATT™ system, a gene of interest can be specifically inserted at a well-characterized, transcriptionally active locus in the mouse genome with guaranteed transgene expression.Tissue specific and / or ubiquitous expression options are
available. Please inquire us for plasmid construct with reporter gene.  We accept international orders.

Available mouse background: FVB or C57BL/6

TARGATT™ Fast & Site-Specific Knockin Mice Service

Advantages of TARGATT™ technology:

1.  Site-specific gene integration at a transcriptionally active locus ensures high level gene expression.

2.  Integration happens at an intergenic region; no internal genes are disrupted.

3. The integrase system catalyzes a unidirectional integration event and results in a high efficiency in producing transgenic mice.

4. Gene integration at the same locus allows a precise comparison of the transgenics from one line to another.

 

 

Application Notes:

Humanized Animal Models