TARGATT™ Fast & Site-Specific Knockin Mice Service
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Do you need a transgenic / knock-in mouse model? Applied StemCell can create site-specific knockin mice for you with a turnaround time as fast as 3 months.
Using our novel TARGATT™ system, a gene of interest can be specifically inserted at a well-characterized, transcriptionally active locus in the mouse genome with guaranteed transgene expression.Tissue specific and / or ubiquitous expression options are
available. Please inquire us for plasmid construct with reporter gene. We accept international orders.
Available mouse background: FVB or C57BL/6
Advantages of TARGATT™ technology:
1. Site-specific gene integration at a transcriptionally active locus ensures high level gene expression.
2. Integration happens at an intergenic region; no internal genes are disrupted.
3. The integrase system catalyzes a unidirectional integration event and results in a high efficiency in producing transgenic mice.
4. Gene integration at the same locus allows a precise comparison of the transgenics from one line to another.
Application Notes:
Humanized Animal Models
- MTA
- Application Guide
- How to use TARGATT
- Comparison Chart with other methods including ZFN
- Presentation
- Service requisition form
