TARGATT™ Fast & Site-Specific Knockin Mice Service
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Do you need a transgenic / knock-in mouse model? Applied StemCell can create site-specific knockin mice for you with a turnaround time as fast as 3 months.
Using our novel TARGATT™ system, a gene of interest can be specifically inserted at a well-characterized, transcriptionally active locus in the mouse genome with guaranteed transgene expression.Tissue specific and / or ubiquitous expression options are
available. Please inquire us for plasmid construct with reporter gene. We accept international orders.
Available mouse background: FVB or C57BL/6
We provide the highest level of customer support. All mouse are shipped from our own California Transgenic Facility.
Advantages of TARGATT™ technology:
Site-specific DNA integration (knockin) in transcriptionally active locus
- Ensures robust gene expression
- Eliminates unpredictable phenotypes caused by random integration
- Allows for proper comparison of different transgenes
Single copy integration
- Eliminates repeat-induced gene silencing and genomic instability.
Insertion of intact transgene
- Avoids broken transgenes with unexpected phenotype
High integration efficiency
Save months of time and costs!
Application Notes:
Humanized Animal Models
- MTA
- Application Guide
- How to use TARGATT
- Comparison Chart with other methods including ZFN
- Presentation
- Service requisition form
