Knock-in / Knock-out Mouse by Homologous Recombination
We provide a high quality service for the generation of gene-targeted knock-in and knock-out mouse models. Our team has decades of experience in vector design, ES cell targeting and mouse handling. We will discuss your project needs with you and custom design your knock-in mouse or knock-out mouse model. Our service includes consultation on available gene targeting vector design strategies and project assessment based on your model requirements.
Service Milestones for the Generation of Knock-in Mouse / Knock-out Mouse Models
Please contact us with any questions regarding services not listed. We are happy to discuss your project with you and design customized strategies. We also offer Transgenic Mouse (Random Insertion) and Transgenic Rat Services including Knock-out Rats and Knock-in Rats.
Testimony of Dr. Zhenheng Guo, PhD, Assistant Professor of Internal Medicine, Division of Endocrinology and Molecular Medicine, University of Kentucky
Project: Germline-transmitted, conditional knock-out mice by tetraploid complementation
"Overall, I am very satisfied with the quality of your service. After we received the mice, we did extensive studies to characterize them. All of the PCR reactions confirm the gene modifications are in the correct sites. We have also crossed mice with Cre mice to demonstrate that the Cre deleted the exon in heterozygous pups as expected. All data obtained showed that the mice were correctly targeted. In addition, I am very happy with the frequent communication with your scientists during the process. I highly recommend your services."
Knock-in Mouse Models
The introduction of a gene into a specified location of the mouse genome can be used for various applications. Mice can be homozygous or heterozygous for the inserted gene.
Knock-out Mouse Models
The knockout technology is most commonly used for gene inactivation, either in a constitutive or conditional fashion.
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