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Careers

COMPANY DESCRIPTION

Applied StemCell Inc. (ASC) is a fast-growing biotechnology company headquartered in the San Francisco Bay area, California. Our goal is to advance gene-editing and stem cell innovation for biomedical research and gene and cell therapy. We are striving to improve and expand our technologies and product lines to bring gene and cell therapy to patients.

We pride ourselves on having an inclusive diverse workforce, with employees from all over the world that bring unique perspectives to our collaborative environment. We deeply value employee ideas and believe in fostering employee growth and development. As a start-up, we are a fast-growing, quick-paced company that provides a strong learning environment for employees to develop critical skills and industrial knowledge.

Our culture is fun, innovative and challenging! For someone to be successful at our company, we need an individual that has the initiative to drive results, can adapt to a fast-changing environment, understands the needs of teamwork, and has the communication skills to confidently share ideas and viewpoints at all different levels within the company.

Applied StemCell is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.


OPEN POSITIONS:

Research Associate, R&D

We are looking for a Research Associate in the R&D department. This is a hands-on lab-based role in the R&D group with a focus on CRISPR gene editing therapy.

Skills and Experience

  • BS degree in biological sciences such as molecular and cell biology, biochemistry, immunology or a related field. MS degree preferred.
  • Experience with culturing human primary cells and cell lines.
  • Molecular biology skills including DNA and RNA isolation, PCR and molecular cloning skills.
  • Experience/training in surface and intracellular staining cells and genome editing cells is a plus.
  • Good oral and written communication skills and organizational skills.
  • Team player
  • Proficient at MS Office

Duties and Responsibilities

  • Perform molecular biological experiments for thalassemia project. It includes cloning, PCR, RT-PCR, E Coli transformation, mini-prep, Maxi, NGS.
  • Culture human cell lines and human primary cells.
  • Work independently to contribute to the design and analysis of experimental procedures.
  • Interpret experimental data and play a significant role in the planning of further experiments.
  • Identify and solve problems associated with the experiments.
  • Conduct where appropriate in parallel more than one agreed area of work to meet timelines.
  • Assist in placing in house order for purchasing needs.
  • Maintains good lab notebook records for easily tracking experiment data.
  • Participates in group meeting and journal club.
To apply, email your coverletter and resume to hr@appliedstemcell.com.
Research Associate, R&D

We are looking for a Research Associate in the R&D department. This is a hands-on lab-based role in the R&D group with a focus on therapeutic protein or antibody bioproduction.

Skills and Experience

  • BS degree in biological sciences such as molecular and cell biology, biochemistry, immunology, protein biochemistry or a related field. MS degree preferred.
  • Experience with culturing different types of mammalian cell lines, suspension and adherent.
  • Molecular biology skills including DNA and RNA isolation, PCR and molecular cloning skills.
  • Hands-on experience with protein expression and purification and protein assay techniques, such as ELISAs, western blots, enzyme assays, etc.
  • Experience/training in protein and antibody engineering and CHO cell area is a plus.
  • Good oral and written communication skills and organizational skills.
  • Team player
  • Proficient at MS Office

Duties and Responsibilities

  • Performs molecular cloning experiment for bioproduction project, which includes vector digestion, RT-PCR, ligation, transformation, mini-prep, midi-prep, etc;
  • Assist in variety type of mammalian cell line culture;
  • Assist in the protein & antibody production process from variety of CHO cell lines.
  • Performs a variety of assays for evaluating yield and function of protein and antibody, such as ELISAs, enzyme assays, etc;
  • Prepare buffer solutions, mediums which are needed for bioproduction project;
  • Assist in placing in house order for purchasing needs;
  • Maintains good lab notebook records for easily tracking experiment data;
  • Participates in group meeting and journal club.
To apply, email your coverletter and resume to hr@appliedstemcell.com.
Quality Assurance (QA) Associate

Skills and Experience

  • B.S. in Biological Sciences or related; Cell Biology, Molecular Biology and/or Genetics major preferred
  • 2 year of experience in QA/QC in Biotech or Pharmaceutical manufacturing; Stem cell and gene editing experience preferred
  • Knowledge of Gel Electrophoresis, PCR, Sanger, Qubit, Hemocytometer and NGS preferred
  • Knowledge of ISO 9001, ISO 13485, Quality Management System (QMS), CAPA System, Document Control, Training, Internal/External Audit processes
  • Strong analytical and organizational skills
  • Excellent Written Communication
  • Interpersonal Skills
  • Keen Attention to Detail
  • Advanced Critical/Logical Thinking
  • Proficient at Microsoft Office

Duties and Responsibilities

  • Document control management including writing, revising, and achieving SOP, protocol, and reports
  • Review and approve manufacturing, receiving inspection, product history files and other quality documents
  • Audit quality management system (QMS), documents, and processes to ensure ISO 9001 and ISO 13485 regulatory compliance are being adhered to
  • Manage incident and CAPA investigations
  • Perform internal audit and external audit of critical supplier
  • Provide training on quality procedures, protocols, and documentation
To apply, email your coverletter and resume to hr@appliedstemcell.com.
Research Associate, Animal (R&D)

The Research Associate will perform in vivo experiments to assist in proof-of-concept experiments and help move projects from discovery stage to preclinical stage. This position is responsible for assisting scientists and research associates in R&D/Therapeutic departments to effectively perform in vivo experiments. Duties include drug administration by subcutaneous, IP, IN, hydrodynamic tail vein injection, tissue/blood sample collection, necropsy, animal colony and health management, breeding, genotyping, phenotyping, DNA/RNA extraction, histology, and etc. Good communication with scientists, research associates, and facility manager is required to ensure that projects are completed in a timely fashion.

Skills and Experience

  • Bachelor's Degree in Biological Science, Genetics, or Animal Science/Biology, Master's degree preferred, ALAT or LAT certification a plus
  • Experience of Animal Handling Experience/Colony Management and Rodent Surgical Procedure preferred
  • Knowledge in Rodent Physiology, Animal Embryology, Genetics, or Genome Editing Technology
  • Effective verbal and written communication skills
  • Team player
  • Highly Developed Awareness of Laboratory Animal Welfare and Responsibility as an Animal User
  • Proficient at MS Office
  • Drug administration skill including subcutaneous, IP and IV
  • Experience with tissue/blood sample collecting

Duties and Responsibilities

  • Animal breeding and phenotyping
  • Animal colony management/health monitoring
  • Drug administration by subcutaneous, IP, IV, hydrodynamic tail vein injection
  • Tissue/blood sample collection and necropsy
  • Histology
  • DNA/RNA extraction/genotyping
  • Documentation
To apply, email your coverletter and resume to hr@appliedstemcell.com.
Document Control Specialist

We are looking for a Document Control Specialist to assist in the management of the QMS document control process, writing SOPs, review and archiving records. 

Skills and Experience

  • High school graduate, B.S. in Science/B.A. in Literature or English preferred
  • 1 year of document control experience, SOP writing and Achieving of Records
  • Knowledge of Quality Management System, ISO 9001, ISO 13485 and FDA 21 CFR preferred
  • Excellent Written Communication
  • Interpersonal Skills
  • Keen Attention to Detail
  • Organizational Skills
  • Proficient at Microsoft Office

Duties and Responsibilities

  • Write, revise and review SOPs
  • Track and control document flow
  • Achieve manufacturing and quality records
  • Ensure auditing and manufacturing documentation is kept up to date
  • Maintenance of Quality Assurance documentation
  • Train Production staff training on quality procedures, protocols, and documentation
To apply, email your coverletter and resume to hr@appliedstemcell.com.
Research Associate, Molecular Biology

We are looking for a Research Associate, Molecular Biology to join our Life Sciences department. This is a hands-on lab-based role in the Life Sciences Service program with a focus on generating engineered cells and animal models using ASC’s gene editing technologies.

Skills and Experience

  • BS degree in biological sciences such as molecular and cell biology, biochemistry, genetics or a related field. MS degree preferred.
  • Molecular biology skills including nucleic acid isolation, PCR, molecular cloning, NGS library prep and sequencing, etc.
  • Experience with protein assays such as western blot and enzyme assays.
  • Knowledge and hand-on experience with CRISPR gene editing technology is a plus.
  • Good oral and written communication skills and organizational skills.
  • Proficient at MS Office

Duties and Responsibilities

  • Work closely with a multi-function team to deliver engineered cell lines and animal models.
  • Performs molecular biology laboratory procedures including DNA/RNA extraction, enzymatic digestion, ligation, transformation, gel electrophoresis, mini and midi DNA preparation, etc. 
  • Prepare samples for Sanger Sequencing and perform NGS library prep, sequencing and data analysis.
  • Follow established protocols and SOPs
  • Maintains good lab records and effectively update results and project status in an informatics system.
  • Participates in group meeting and present technical data

To apply, email your coverletter and resume to hr@appliedstemcell.com.

Research Associate, Cell Biology (iPSCs)

We are looking for a Senior Research Associate to join our Life Sciences department. This is a hands-on lab-based role in Induced Pluripotent Stem Cells (iPSCs) group with a focus on iPSC genome engineering and differentiation using ASC’s gene editing technologies.

Skills and Experience

  • BS degree in biological sciences such as cell biology, developmental biology, molecular biology, genetics or a related field. MS degree preferred.
  • 1-2 years’ experience with iPSCs and/or stem cell culture systems, cell transfection, FACS etc.
  • Hands-on experience with iPSCs generation and differentiation.
  • Knowledge and hand-on experience with CRISPR gene editing technology is a plus.
  • Good oral and written communication skills and organizational skills.
  • Proficient at MS Office

Duties and Responsibilities

  • Work closely with a multi-function team to deliver engineered iPSCs cell lines and a variety of other cell types.
  • Work on gene editing projects in iPSCs/stem cells, preparing reagents, performing cell culture and cell-based assays.
  • Work on iPSCs generation, differentiation and characterization.
  • Apply scientific knowledge, critical thinking, and problem-solving abilities to troubleshoot and refine methods and assays
  • Interpret genotyping data from Sanger sequencing and Nextgen sequencing
  • Follow established protocols and SOPs
  • Maintains good lab records and effectively update results and project status in an informatics system.
  • Participates in group meeting and present technical data

To apply, email your coverletter and resume to hr@appliedstemcell.com.

Research Associate, Cell Biology

We are looking for a Research Associate to join our Life Sciences department. This is a hands-on lab-based role in cell biology group with a focus on generating engineered cell lines using ASC’s gene editing technologies.

Skills and Experience

  • BS degree in biological sciences such as cell biology, developmental biology, molecular biology, genetics or a related field. MS degree preferred.
  • Significant experience with mammalian cell culture, cell transfection, FACS etc.
  • Experience with culturing difficult/challenging cell lines is a plus.
  • Knowledge and hand-on experience with CRISPR gene editing technology is a plus.
  • Good oral and written communication skills and organizational skills.
  • Proficient at MS Office

Duties and Responsibilities

  • Work closely with a multi-function team to deliver engineered cell lines.
  • Work on gene editing projects in a variety of cell types, preparing reagents, performing cell culture, cell cloning and cell-based assays.
  • Interpret genotyping data from Sanger sequencing and Nextgen sequencing
  • Follow established protocols and SOPs
  • Maintains good lab records and effectively update results and project status in an informatics system.
  • Participates in group meeting and present technical data

To apply, email your coverletter and resume to hr@appliedstemcell.com.