Humanized Strategy
Validation Data
Figure 1. Expression characterization of hCD28 on T cells in blood in hCD28 KI mice
Figure 2. Expression characterization of hCD28 on T cells in spleen in hCD28 KI mice
Figure 3. Expression characterization of hCD28 on T cells in thymus in hCD28 KI mice
Figure 4. In vivo efficacy study in CD28 humanized mice grafted with MC38-hPDL1 tumor model