Applied StemCell has developed an efficient integration-free, small molecule-based method to differentiate high-quality retinal pigment epithelium (RPE) precursor cells from human iPSCs. The differentiated RPE cells recapitulate the phenotype and functional parameters of primary and in vivo RPE cells.
We provide RPE cells differentiated from an integration-free, control human iPSC line (ASE-9211), reprogrammed from the fibroblasts of an African-American male donor. These high-purity (≥90%) cells express high levels of RPE biomarkers, PMEL1, MITF, ZO-1, and RPE65