Isogenic Cell Lines

Applied StemCell, Isogenic

 

Isognic Cell Lines for Drug Dicovery: Isogenic cell lines represent a unique toolset for studying the impact of genotype on cellular phenotype.  

 isogenic

 

Isognic Cell Lines for Drug Dicovery: Isogenic cell lines represent a unique toolset for studying the impact of genotype on cellular phenotype.  An isogenic cell line is a cell line that has been engineered from a parental line through the introduction of a targeted gene mutation. In doing so, the parental cell line inherently becomes a control line to which the engineered line can be referenced. Isogenic cell line pairs can be incredibly useful as tools for studying cellular biology, such as the impact of genotype on cellular phenotype, as well as for parallel, high throughput screening to enable the discovery of therapeutic compounds that exhibit genotype-specific toxicity. Applied StemCell offers a number of homozygous isogenic cell lines.  For enabling discoveries in cancer biology and therapeutics, our MAPK mutation series features diverse oncogenic driver mutations in the MAPK pathway.  For genome engineering applications, we also offer cell lines that have been modified to enable more efficient genome editing, such as our Cas9-expressing Jurkat line, and hiPSC TARGATT™ Master line.  In addition to off-the-shelf products, Applied StemCell offers custom cell line engineering services in order to generate knock-out, point mutation, knock-in, inducible, and reporter cell lines.