Reference Standards

Applied StemCell Tissue Slides

Reference Standards

  • We offer validated, cellular and molecular reference standards that  accelarate diagnostic assay development. In addition, our reference standards are employed in sample processing workflows assessment, or as quality controls by clinical diagnostics laboratories during validation.

Why Use Reference Materials?

  • Reference materials for biologics  provide a consistent and reliable resource for evaluating and optimizing various stages of your sample processing workflow.  Whether you’re starting from DNA extraction, assay design, or library preparation, our reference materials can help you to identify and eliminate sources of variability within your protocols. Our reference standards for biologics is ideal for companion diagnostic assay development. 
  • To learn more about the ONCOREF™ products, WATCH our WEBINAR!

Molecular Reference Materials Enables  You  To:

  • Optimize your DNA extraction protocols prior to using valuable patient samples
  • Monitor the impact of workflow changes on downstream results using consistent, third-party validated standards
  • Establish limits of detection (LODs) using mixtures of isogenically-paired, mutant and wild-type DNA
  • Utilize standardized materials to easily transfer workflows across labs or institutions
  • Accurately evaluate batch-to-batch variability to streamline your quality control process
  • Our reference standards for biologics are ideal for companion diagnostic assay development. 

Applications:

Our cellular or molecular reference materials can be used for various histological or genetic analysis methodologies.

  • Immunohistochemistry (IHC)
  • H&E staining 
  • in situ hybridization (ISH)
  • DNA sequencing (Sanger, Next-Generation Sequencing)
  • PCR (quantitiative real-time or digital)
  • DNA microarray 

 Multiple Product Formats Available:

  • ONCOREF™ Genomic DNA (gDNA)

    The ONCOREF™ Genomic DNA (gDNA) Reference Standards represent biologically-relevant control material that can be used for diagnostic assay development or can be used in routine monitoring of assay performance in a CLIA laboratory environment.  The ONCOREF™ Genomic DNA (gDNA) Reference Standards can be directly incorporated into the sample processing workflows for assay optimization, evaluate assay sensitivity and specificity, and analyze the impact of workflow changes on downstream analysis. 

  • ONCOREF™ Frozen Cell Pellet

    The ONCOREF™ Frozen Cell Pellet is a product devived from our mutated isogenic cell line.  It is a biologically-relevant reference material that can be used to experiment formalin-fixation's effect on nucleic acid integrety in the pressence of celluar debris.  

  • ONCOREF™ Custom FFPE Service

    Our ONCOREF™ Custom FFPE Service uses a patent-pending process to generate highly homogenous FFPE blocks with any desired cell density (up to 90% area coverage). Both morphology and biological molecules, including protein and nucleic acid (DNA and RNA) targets are well preserved for IHC and ISH analysis.

  • ONCOREF™ FFPE Mutated Cell Scrolls

    Our Isogenic cell line-based FFPE reference standards represent ideal materials for diagnostic assay development and routine quality control purposes. ONCOREF™ FFPE Mutated Cell Scrolls provides precision-edited, isogenically-paired, mutant and wild-type FFPE reference standards is a great resource for diagnostic assay development and quality control purposes.  ONCOREF™ footprint-free genome editing technology for cell line generation enable precise mutation generation without concerns of genomic scar incorporation from the use of selection markers or other footprint-based technologies.

  • ONCOREF™ FFPE Mutated Cell Slides

    The ONCOREF™ FFPE Mutated Cell Slides are perfect controls for Immunohistochemical (IHC) applications.  Cells can be harvested by standard trypsinization or a proprietary trypsin-free method to best preserve cell surface antigens while inflicting minimal physical damage that leads to loss of biomarkers. Nucleic acids (DNA/RNA) are perfectly preserved in the ONCOREF™ FFPE Mutated Cell Slides sections (5µm) and are ready for DNA and RNA in situ hybridization (ISH) analysis.

  • ONCOREF™ FFPE Mutated Cell Blocks

    ONCOREF™ FFPE Mutated Cell Blocks products provides a reliable and renewable source of clinically relevant specimens for assay development, and for routine clinical laboratory quality control (QC).

  • ONCOREF™ FFPE Human Cancer Tissue Derived Cell Line Slides

    We offers slide-mounted FFPE cancer tissue derived cell line sections slides from 34 common cancer cell lines, derived from 10 different tissues of origin.  Our FFPE cell pellets are prepared using a patent-pending process that generates highly homogenous FFPE blocks with any cell density (up to 90% area coverage). Both morphology and biological molecules, including protein and nucleic acid (DNA and RNA) targets are well preserved for IHC and ISH analysis.

  • ONCOREF™ Multiplex Quantitative Reference Standards (Coming soon!)

    The ONCOREF™  Multiplexed Quantitative Reference Standards allows you to simultaneously validate your assay performance across multiple loci and genetic alterations using PCR or next-generation sequencing (NGS) or digital PCR. 

  • TISSUREF™ FFPE Mouse Tissue Slides

    The TISSUREF™  FFPE Mouse Tissue Slides used a patent-pending process that generates highly homogenous FFPE sections with consitant and equallly distributed cell density.  Both morphology and biological molecules, including protein and nucleic acid (DNA and RNA) targets are well preserved for IHC and ISH analysis.

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