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Knockout, Knock-in, Point Mutation Mouse Models

Applied StemCell utilizes its in-licensed CRISPR/Cas9 technology to generate mouse models with precise gene modifications such as knockout, gene knock-in and point mutation models for a variety of research and preclinical applications. As one of the earliest licensees of the technology and service provider of this technology, we have generated > 200 mouse models with very high efficiency and success rate. Our affordable custom service options and do-it-yourself kits uses upgraded designing strategies, highly optimized CRISPR protocols and validation methods to generate mouse models successfully with a fast turnaround and reduced cost. 

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Key Features:

  • Most up-to-date CRISPR designing strategies and protocols
  • 100% target-site cutting efficiency using optimized, proprietary gRNA validation methods
  • > 50% efficiency and >99% success rate in generating final mouse model
  • ISO:9001 certified facility for manufacturing high quality CRISPR reagents for microinjection
  • AAALAC-accredited animal facility in the USA for engineering mouse models
  • Wide variety of genome modifications to generate a mouse model for your research specifications
  • F1 breeding to confirm germline transmission for service projects
  • Animal IP belongs to researchers
  • NEW! Electrophysiology and behavioral assessments for your custom mouse models
  • Dedicated project management and timely milestone and final reports