TARGATT™ “attP” Mouse; Male-Female Breeding Pairs
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The TARGATT™ “attP” mice (C57BL/6J) contain the PhiC31 integrase recognition site, attP at the mHipp11 (H11) safe harbor locus on mouse chromosome 11. The male attP mice are homozygous for the attP site and are used for breeding with wild-type female mice for establishing a TARGATT™ mouse colony in your vivarium.
The female TARGATT™ mice in the colony can be used as embryo donors for the pronuclear microinjection of the TARGATT™ donor plasmid containing the “attB” site and the gene of interest. When injected together with the PhiC31 integrase mRNA, the transgene becomes permanently integrated into the embryo attP site. These mice can be used for site-specific and stable integration of your transgene into the H11 safe harbor locus in the mouse genome.
Ideal For: Inducible Gene Expression, Overexpression of gene of interest, Reporter genes, Humanized models, and Gene knockdown (siRNA expressing transgenes).
Health report available upon request.
Explore our list of book chapters and citations/ publications for the various types of transgenic mice that researchers have engineered using the TARGATT™ technology.