GITR - Immune Checkpoint Mouse Models - Mouse Repository - Animal Models - Research

SKU :
ASHU-00096
Catalog # :
ASHU-00096
Availability :
Mouse
Humanized Strategy Validation of Humanized GITR Expression by FACS Figure 1. Expression of humanized GITR in the spleen lymphocytes of humanized GITR mice is detected by FACS. Staining of spleen lymphocytes collected from heterozygous humanized GITR mice, while the expression of humanized GITR is detected by FACS. The results showed that the active expression of humanized GITR can be detected in the spleen lymphocytes collected from heterozygous humanized GITR mice. Figure 2. Detection .....
Inquire
Questions ? Contact Us
Strain Information
  • Catalog Number ASHU-00096
  • Model Name GITR
  • Strain Name C57BL/6J - Tnfrsf18em1(hTNFRSF18) Asc
  • Mutation Type Humanized
  • GENE Synonyms AITR, Gitr
  • Human Orthologs TNFRSF18
  • Emsamble ID ENSMUSG00000041954
  • MGI ID 894675
  • NCBI ID 21936
  • Backgound C57BL/6J
  • Coat Color Black
  • Mutation Type Humanized
Description

Humanized Strategy

Landingpage-ASHU-00096-GITR-HU-ICPMouse-1

Validation of Humanized GITR Expression by FACS

Landingpage-ASHU-00096-GITR-HU-ICPMouse-2

Figure 1. Expression of humanized GITR in the spleen lymphocytes of humanized GITR mice is detected by FACS. Staining of spleen lymphocytes collected from heterozygous humanized GITR mice, while the expression of humanized GITR is detected by FACS. The results showed that the active expression of humanized GITR can be detected in the spleen lymphocytes collected from heterozygous humanized GITR mice.

Landingpage-ASHU-00096-GITR-HU-ICPMouse-3

Figure 2. Detection of GITR expression in peripheral blood cells of humanized GITR mice. The FACS results of peripheral blood cells showed that the active expression of humanized GITR was detected in T cells collected from heterozygous humanized GITR mice. (Data in partnership with collaborators).

Research Application
Immunotherapy
Availability
Mouse
Google