CD3E - Immune Checkpoint Mouse Models - Mouse Repository - Animal Models - Research

SKU :
ASHU-00114
Catalog # :
ASHU-00114
Availability :
Mouse
Humanized Gene Knock-in Strategy Validation Data   Figure 1. The expression of human CD3E in the peripheral blood cells derived from heterozygous or homozygous humanized mice was confirmed by FACS.  Figure 2. Detection of T cell subsets in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice. Figure 3. Detection of B and NK cells in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice. Figure 4. In vitro T ce .....
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Strain Information
  • Catalog Number ASHU-00114
  • Model Name CD3E
  • Strain Name C57BL/6J - Cd3eem1(hCD3E) Asc
  • Mutation Type Humanized
  • GENE Synonyms CD3, T3e, AI504783, CD3epsilon
  • Human Orthologs CD3E
  • Emsamble ID ENSMUSG00000032093
  • MGI ID 88332
  • NCBI ID 12501
  • Backgound C57BL/6J
  • Coat Color Black
  • Mutation Type Humanized
Description

Humanized Gene Knock-in Strategy

Landingpage-ASHU-00114-CD3E-HU-ICPMouse-1

Validation Data

landingpage-ashu-00114-cd3e-hu-icpmouse-2.01

 

Figure 1. The expression of human CD3E in the peripheral blood cells derived from heterozygous or homozygous humanized mice was confirmed by FACS. 

landingpage-ashu-00114-cd3e-hu-icpmouse-3.01

Figure 2. Detection of T cell subsets in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice.

landingpage-ashu-00114-cd3e-hu-icpmouse-4.01

Figure 3. Detection of B and NK cells in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice.

landingpage-ashu-00114-cd3e-hu-icpmouse-5.01

Figure 4. In vitro T cell activation with heterozygous or homozygous CD3E humanized mice.

Research Application
Immunotherapy
Availability
Mouse
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