ANGPTL3

SKU :
ASHU-200113
Catalog # :
ASHU-200113
Availability :
Mouse

ANGPTL3

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Strain Information
  • Catalog Number ASHU-200113
  • Model Name ANGPTL3
  • Strain Name C57BL/6-Angptl3tm1(hANGPTL3)/Asc
  • Mutation Type Humanized
  • GENE Synonyms hypl
  • Human Orthologs ANGPTL3
  • Emsamble ID ENSMUSG00000028553
  • MGI ID 1353627
  • NCBI ID 30924
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
Description

Validation Data

landingpage-ashu-200113-angptl3-hu-icpmouse-1

Figure1. Analysis of ANGPTL3 gene expression on hepatocytes by RT-PCR in WT and ANGPTL3 humanized mice.

Mouse Angptl3 mRNA was detectable by P1/2(443bp), human ANGPTL3 mRNA was detectable by P3/4(345bp).

M:100bp Plus DNA ladder from Transgen (BM311). RT-PCR results showed that hepatocytes of the heterozygous KI mice express both human ANGPTL3 and mouse Angptl3.

landingpage-ashu-200113-angptl3-hu-icpmouse-2

Figure 2.  Analysis of human ANGPTL3 expression in serum by ELISA in the ANGPTL3 humanized mice. The heterozygous KI mice express human ANGPTL3 in serum.

Research Application
Cardiovascular research, drug screening
Availability
Mouse
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