PD-1 - Immune Checkpoint Mouse Models - Mouse Repository - Animal Models - Research

SKU :
ASHU-190079
Catalog # :
ASHU-190079
Availability :
Mouse
Validation Data Figure 1. Expression of PD-1 in the activated spleen lymphocytes of homozygous humanized PD-1 BALB/c KI mice is detected by FACS. Figure 2. In vivo validation of homozygous BALB/c-hPD1 mice. The homozygous BALB/c-hPD1 mice were inoculated with CT26 cells, and randomly assigned to different groups (n=7) when the tumor grew to a volume of 100 mm3. A combinatorial treatment of anti-hPD1 antibody Keytruda  and entinostat (ENT; a class I HDAC inhibitor) demonstrated a not .....
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Strain Information
  • Catalog Number ASHU-190079
  • Model Name PD-1
  • Strain Name BALB/c-Pdcd1em1(hPDCD1)Asc
  • Mutation Type Humanization
  • GENE Synonyms PD-1, Pdc1, Ly101
  • Human Orthologs PDCD1
  • Emsamble ID ENSMUSG00000026285
  • MGI ID 104879
  • NCBI ID 18566
  • Backgound BALB/c
  • Coat Color Black
  • Mutation Type Humanization
Description

Validation Data

Landingpage-ASHU-190070-PD-1-HU-ICPMouse-1

Figure 1. Expression of PD-1 in the activated spleen lymphocytes of homozygous humanized PD-1 BALB/c KI mice is detected by FACS.

Landingpage-ASHU-190079-PD-1-HU-ICPMouse-2

Landingpage-ASHU-190079-PD-1-HU-ICPMouse-3

Figure 2. In vivo validation of homozygous BALB/c-hPD1 mice. The homozygous BALB/c-hPD1 mice were inoculated with CT26 cells, and randomly assigned to different groups (n=7) when the tumor grew to a volume of 100 mm3. A combinatorial treatment of anti-hPD1 antibody Keytruda  and entinostat (ENT; a class I HDAC inhibitor) demonstrated a noticeable efficacy improvement compared to the same dose of single agent (A) without affecting the animal body weight (B).

Landingpage-ASHU-190070-PD-1-HU-ICPMouse-4

Landingpage-ASHU-190079-PD-1-HU-ICPMouse-5

Figure 3. In vivo validation of homozygous BALB/c-hPD1 mice. The homozygous BALB/c-hPD1 mice were inoculated with CT26 cells, and randomly assigned to different groups (n=6) when the tumor grew to a volume of 65 mm3. A combinatorial treatment of anti-hPD1 antibody Opdivo  and anti-mCTLA antibody demonstrated a noticeable efficacy improvement compared to the same dose of single agent (A) without affecting the animal body weight (B). (Data in partnership with collaborators)

Research Application
Immunotherapy, cancer research, drug screening
Availability
Mouse
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