Lyz2-IRES-DTREGFP

SKU :
ASKI-190041
Catalog # :
ASKI-190041
Availability :
Mouse

Lyz2-IRES-DTREGFP

Inquire
Questions ? Contact Us
Strain Information
  • Catalog Number ASKI-190041
  • Model Name Lyz2-IRES-DTREGFP
  • Strain Name C57BL/6-Lyz2em3(IRES-DTREGFP)/Asc
  • Mutation Type Knock-in
  • GENE Synonyms Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp
  • Human Orthologs LYZ
  • Emsamble ID ENSMUSG00000069516
  • MGI ID 96897
  • NCBI ID 17105
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Knock-in
Description

Validation Data

landingpage-aski-190041-Lyz2-IRES-DTRGFP-ki-mouse-1

 

Figure 1: Analysis of GFP expression by FACS. The Lyz2-DTRGFP mouse expresses GFP on CD11b+ cells.

landingpage-aski-190041- Lyz2-IRES-DTREGFP-ki-mouse-2

Figure 2: Analysis of the level of different immune cells in PBMC by FACS (See Figure 4 for details of diphtheria toxin injection). 

landingpage-aski-190041-Lyz2-IRES-DTREGFP-ki-mouse-3

Figure 3: Analysis of the level of different immune cells in the spleen and transplanted tumor by FACS (See Figure 4 for details of diphtheria toxin injection). 

landingpage-aski-190041-Lyz2-IRES-DTREGFP-ki-mouse-4

Figure 4: The growth of MC38 tumors in Lyz2-DTRGFP mice and C57BL/6 mice.  Heterozygous Lyz2-DTRGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. The Lyz2-DTRGFP mice were injected with diphtheria toxin twice a week. (Data in partnership with collaborators.)

Research Application
Immunotherapy, DTR mouse
Availability
Mouse
Google