*Humanized CD34+ (hu-CD34+-M-NSG) male mice are available by custom request only.
HSC Humanized Mice
General Information
Preparation
Figure 1. Preparation process of M-NSG mice transplanted with human hematopoietic stem cells (HSCs).
Phenotypic Analysis
Figure 2. Reconstructed hematopoietic system of M-NSG mice transplanted with human hematopoietic stem cells (HSCs), indicating continuously increased level of human-derived CD45+ immune cells in peripheral blood.
Figure 3. Proportions of various types of hematopoietic/immune cells at 20 weeks after the mice are transplanted with human hematopoietic stem cells (HSCs), including human-derived T (CD3+CD4+ and CD3+CD8+ cells), B (CD19+ cells), NK lymphocytes (CD56+CD16+ cells), and monocytes (CD14+CD11b+ cells).
Figure 4. Reconstructed hematopoietic system of M-NSG mice transplanted with human hematopoietic stem cells (HSCs), with supplementation of human-derived IL-15, which can significantly increase the proportion of NK cells and is suitable for the efficacy evaluation of drug targets on NK cells.
Efficacy Evaluation
Figure 5. Example 1 of anti-tumor efficacy validation in Hu-HSC tumor-bearing mouse model
Figure 6. Example 2 of anti-tumor efficacy validation in Hu-HSC tumor-bearing mouse model
Study-ready cohorts of hu-PBMC humanized mice are provided upon request. We can ship to your institution or for enrollment in customized drug/antibody efficacy studies executed by our In Vivo Assay Services team.
Shipment is for the US only.
Questions or request case studies?
Contact info@appliedstemcell.com