• Rat Models

Cre Rat Models

These transgenic Cre rat models can enable the developed of physiologically relevant human cardiovascular or neurological diseases using either ASC's proprietary integrase-based TARGATT™ System or CRISPR/cas9 genome editing technology.   

These products were supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R44GM108071. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health


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Technical Details

Tissue/Cell-specificity

Rat line

Promoter

Reference

Developing neural crest and midbrain

Wnt1-CreERT2

1.3-kb 5' promoter and 5.5 kb 3' enhancer of the mouse Wnt1, wingless-related MMTV integration site 1

Chou et al 2013

Neurons of cortex, cerebellum, brain stem, spinal cord and olfactory bulb

PDGF-CreERT2

1.425-kb (-1360 to +75 relative to transcription start site) of the human PDGF B-chain gene

Sasahara et al 1991

Olfactory sensory neuronal lineage

MOR23-CreERT2

2.2-kb of mouse MOR23 promoter

Li et al 2004

Vassalli et al 2002

Neurons involved in the control of food intake (arcuate nucleus (hypothalamus) and solitary tract nucleus (hindbrain))

Pomc-CreERT2

13-kb of 5′ and 2 kb of 3′ mouse Pomc flanking sequences

 

Padilla et al 2011

Young et al 1998

Motor neurons

HB9-CreERT2

9-kb HB9 promoter

Arber et al 1999 Yang et al 2001; Nakano et al 2005; Tasic et al 2011

Dopamine D1 receptor-expressing neurons

Drd1a-CreERT2

8-kb mouse Drd1 promoter

 

Zhang et al 2006

GABAergic neurons, islet cells and spermatocytes

GAD67-CreERT2

 

10.2-kb containing 8.4-kb promoter and noncoding exon 0A and 0B of mouse glutamate decarboxylase 67

Kabayashi et al 2003

Rasmussen et al 2007

Glutamatergic neurons

PAG-CreERT2

2.4-kb rat PAG (phosphate-activated glutamase) promoter

Rasmussen et al 2007

Astrocytes in CNS

GFAP-CreERT2

2.2-kb human GFAP (glial fibrillary acidic protein)

Brenner et al 1994

Vascular endothelial cells including brain and retinal capillary

Tie2-CreERT2

2.1-kb promoter +1.7kb intron 1 enhancer of mouse Tie2 (vascular endothelial-specific receptor tyrosine kinase)

Schlaeger et al 1997

Ohtsuki et al 2005

Vascular smooth muscle cells

SMHC-CreERT2

2.3-kb rabbit smooth muscle myosin heavy chain promoter

Franz et al 1999

Cre reporter/test line expressing GFP and lacZ

CA-LoxP-STOP-LoxP-GFP-LacZ

1.7-kb CA (CMV-beta-actin) promoter

Tasic et al 2011

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