TARGATT™ Cre-Rat with GFAP-CreERT2 Promoter (Rat) - Cre Rat Models - Rat Models - Animal Models - Research

SKU :
558-2
Catalog # :
558-2
MTA required. This conditional Cre-Rat also contains the Cre recombinase gene paired with GFAP-CreERT2 promoter construct which targets the astrocytes in neurons and is inserted into the H11 safe harbor locus using Applied Stemcell’s proprietary integrase-based TARGATT™ technology and is guaranteed expression of the Cre gene driver by the chosen promoter. Furthermore, DNA recombinase activity is induced by Tamoxifen, so that this transgenic rat model will be conditional and .....
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Description

MTA required. This conditional Cre-Rat also contains the Cre recombinase gene paired with GFAP-CreERT2 promoter construct which targets the astrocytes in neurons and is inserted into the H11 safe harbor locus using Applied Stemcell’s proprietary integrase-based TARGATT™ technology and is guaranteed expression of the Cre gene driver by the chosen promoter. Furthermore, DNA recombinase activity is induced by Tamoxifen, so that this transgenic rat model will be conditional and inducible.

Tissue/Cell-specificity

Rat line

Promoter

Reference

Astrocytes in CNS

GFAP-CreERT2

2.2-kb human GFAP (glial fibrillary acidic protein)

Brenner et al 1994

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