TARGATT™ Cre-Rat with PDGFb-CreERT2 Promoter (Rat) - Cre Rat Models - Rat Models - Animal Models - Research

SKU :
551-2
Catalog # :
551-2
MTA required.  This PDGFb-CreERT2 conditional Cre-Rat also contains the Cre recombinase gene paired with PDGFb-CreERT2 promoter construct which targets the cortex neurons and is inserted into the H11 safe harbor locus using Applied Stemcell’s proprietary integrase-based TARGATT™ technology and is guaranteed expression of the Cre gene driver by the chosen promoter. Furthermore, DNA recombinase activity is induced by Tamoxifen, so that this transgenic rat model will be c .....
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Description

MTA required.  This PDGFb-CreERT2 conditional Cre-Rat also contains the Cre recombinase gene paired with PDGFb-CreERT2 promoter construct which targets the cortex neurons and is inserted into the H11 safe harbor locus using Applied Stemcell’s proprietary integrase-based TARGATT™ technology and is guaranteed expression of the Cre gene driver by the chosen promoter. Furthermore, DNA recombinase activity is induced by Tamoxifen, so that this transgenic rat model will be conditional and inducible.

Tissue/Cell-specificity

Rat line

Promoter

Reference

Neurons of cortex, cerebellum, brain stem, spinal cord and olfactory bulb

PDGF-CreERT2

1.425-kb (-1360 to +75 relative to transcription start site) of the human PDGF B-chain gene

Sasahara et al 1991

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