Knockout, Knock-in, Point Mutation Rat Models
Applied StemCell (ASC) leverages its long-standing expertise in CRISPR/Cas9 technology, as well as animal model engineering to generate rat models with precise gene modifications for a variety of research and preclinical applications.
Up-to-date CRISPR design strategies
100% target-site cutting efficiency using validated gRNA
Highly successful at generating final rat model
ISO:9001 certified facility for manufacturing CRISPR reagents
AAALAC-accredited animal facility in the USA
Wide variety of genome modifications available
F1 breeding to confirm germline transmission
Animal IP belongs to researchers
Electrophysiology and behavioral assessments for your rat models
Learn about our CRISPR Rat Model Generation Service
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At an affordable price, take advantage of Applied StemCell CRISPR rat model generation services. We use advanced CRISPR/ Cas9 gene targeting strategies, highly optimized CRISPR protocols and validation methods to generate a rat model specific to your requirements.
How CRISPR/ Cas9 works:
For large transgene knock-in and conditional knockout rat models, we also provide services using other gene modification methods such as site-specific TARGATT™ integrase-based gene integration or BAC-mediated random transgene knock-in.
You can choose between two service options for BAC-mediated transgene knock-in:
1. Full service custom rat model generation
2. BAC modification strategy and cloning (you can do the pronuclear injection and transgenic rat screening)