Genome Edited iPSCs (KO) PARK2-/-, Parkinson's Disease (PD), Biallelic KO *Academic Price - Genetically Modified Cell Lines / Isogenic Cell Lines - Products - Research

* Price listed above is for academic institutions for research purposes only

MTA is required

Applied StemCell's Genome Edited series of iPSC lines are ideal as in vitro models for neurodegenerative diseases such as Parkinson’s Disease, Alzheimer’s Disease, ALS, Autism and more. The ASE-9400 iPSC line is engineered with a bi-allelic (homozygous) knockout for PARK2 gene (PARK2^-/-) that has been implicated in familial etiology of Parkinson’s disease. The parental iPSC is ASE-9109 which is an integration-free, normal karyotype iPSC derived from male, CD34+ cord blood cells. The PARK2 knockout line can be further differentiated into an isogenic panel of neurons and glia for disease modeling and drug/ toxicity screening applications.