Genome Edited iPSCs (KO) CNTNAP2-/-, Autism, Biallelic KO *Academic Price - Neuronal Disease Specific Isogenic Knockout iPSCs - Genetically Modified Cell Lines / Isogenic Cell Lines - Products - Research

* Price listed above is for academic institutions for research purposes only

MTA is required

Applied StemCell's Genome Edited series of iPSC lines are ideal as in vitro models for neurodegenerative diseases such as Parkinson’s Disease, Alzheimer’s Disease, ALS, Autism and more. The ASE-9408 iPSC line is engineered with a bi-allelic (homozygous) knockout for CNTNAP2 gene (CNTNAP2^-/-) that has been implicated in Autism Spectrum Disorder (ASD) as well as other neurodevelopmental disorders. The parental iPSC is ASE-9109 which is an integration-free, normal karyotype iPSC derived from male, CD34+ cord blood cells. The CNTNAP2 knockout line can be further differentiated into an isogenic panel of neurons and glia for disease modeling and drug/ toxicity screening applications.