Genome Edited iPSCs (KO) BDNF-/-, Central Nervous System Disease (CNS), Biallelic KO *Academic Price - Stem Cell - Products - Research

* Price listed above is for academic institutions for research purposes only

MTA is required

Applied StemCell's Genome Edited series of iPSC lines are ideal as in vitro models for neurodegenerative diseases such as Parkinson’s Disease, Alzheimer’s Disease, ALS, Autism and more. The ASE-9404 iPSC line is engineered with a bi-allelic (homozygous) knockout for BDNF gene (BDNF^-/-), a gene essential for optimal brain function and whose dysfunction has been implicated in neurological disorders. The parental iPSC is ASE-9109 which is an integration-free, normal karyotype iPSC derived from male, CD34+ cord blood cells. The BDNF knockout line can be further differentiated into an isogenic panel of neurons and glia for disease modeling and drug/ toxicity screening applications.