Microglia Differentiation Service from iPSC

Microglia Differentiation Service Details

• Standard
• Fully Customizable Service - Inquire

Standard Packaging:

• Ship 1-2 million iPS cells (1-2 cryovials; 1 million cells/vial); OR
  • With pathogen and SARS-CoV-2 test results
    • Optional Pathogen Testing Service is available
• Select one of our Control iPS Cell Lines; OR
• Let ASC generate your iPSCs from your human or non-human samples

Standard Deliverables:

• Cryopreserved iPSC-derived microglia
• Antibody staining images and/or flow cytometry data for the cell type-specific markers
  • IBA1, TMEM119, P2RY12, CX3CR1, TREM2; other markers available upon request
• Recovery Test, Mycoplasma Test
• Sub-culture protocol and media (optional)
• Other markers (available upon request)

Standard Workflow and Timeline:

Timeline = 2 months

Optional! RT-PCR, Western Blot, proliferation assays, phagocytosis, functional assay

Applications:

• Neurodevelopment and neuroinflammation research
• Disease modeling for neuroinflammation and neurodegenerative diseases
• Mimic in vivo environment by co-culture with iPSC-derived neurons and glial cells for cell-cell interaction studies and signaling pathway
• In vitro and in vivo (adoptive transfer) cell line model to investigate microglial dysfunction in CNS disorders
• High throughput drug target discovery, efficacy, and toxicity testing