Astrocytes Differentiation Service from iPSC

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Astrocyte Differentiation Service Details

iPSC-derived astrocytes are cells that are generated from induced pluripotent stem cells (iPSCs), which are reprogrammed adult cells that have the ability to differentiate into many different cell types, including astrocytes. Astrocytes are star-shaped glial cells in the central nervous system that play important roles in supporting and protecting neurons.

The generation of iPSC-derived astrocytes involves a process of differentiation that mimics the natural development of astrocytes in the developing embryo. This process involves the sequential activation of different genes and signaling pathways that direct the iPSCs towards an astrocyte fate.

iPSC-derived astrocytes have several important applications in research and medicine. For example, they can be used as a model for studying neurological diseases and drug toxicity. By generating astrocytes from iPSCs derived from patients with neurological diseases, researchers can study the disease mechanisms and test potential therapies in a dish.

In addition, iPSC-derived astrocytes have the potential to be used in regenerative medicine. For patients with neurological damage or diseases, transplantation of healthy astrocytes could be a potential treatment option. Astrocytes are involved in many important functions in the nervous system, including the regulation of neurotransmitter levels, the maintenance of the blood-brain barrier, and the protection of neurons from oxidative stress and inflammation. iPSC-derived astrocytes could offer a potential alternative, providing a source of functional astrocytes that can be generated in large quantities and tailored to individual patient needs.

Overall, the generation of iPSC-derived astrocytes has the potential to advance our understanding of neurological diseases and lead to new therapies for patients with neurological conditions.

Standard Packaging:

  • Ship 1-2 million iPS cells (1-2 cryovials; 1 million cells/vial); OR
    • With pathogen and SARS-CoV-2 test results
      • Optional Pathogen Testing Service is available
  • Select one of our Control iPS Cell Lines; OR
  • Let ASC generate your iPSCs from your human or non-human samples

Standard Deliverables:

  • Cryopreserved iPSC-derived astrocytes
  • Antibody staining images and/or flow cytometry data for the cell type-specific markers
    • GFAP & S100beta
  • Recovery Test, Mycoplasma Test
  • Sub-culture protocol and media (optional)
  • Other markers (available upon request)

Standard Workflow and Timeline:

Turnaround Time: 2 months

Optional! RT-PCR, Western Blot, proliferation assays, calcium activity assays, cytokine-mediated inflammatory response assays 


  • Co-culture with neurons for advanced, in vivo-like cell line models
  • Neurotoxicity screening
  • Disease modeling
  • High throughput drug discovery and drug screening applications
  • Drug neurotoxicity screening applications