Knockin Mouse Model Generation

Applied StemCell offers custom knockin mouse model generation service using two complementary technologies, CRISPR/Cas9 and TARGATT™ site-specific integration technologies that vastly expand the portfolio of knockin modifications we can offer gene-specific knockin (up to 6 kb) or safe harbor locus knockin (up to 10kb with CRISPR and up to 22 kb with TARGATT™). We offer several genetic modifications: point mutation, humanized gene knockin/ replacement, reporter mouse models, safe harbor locus models with CRISPR (Rosa26, H11, AAVS1) or TARGATT™ (Rosa26, H11 or a custom locus).