Immunodeficient Mouse Models : M-NSG Mouse Models

Applied StemCell offers a variety of immunodeficient mouse models, including our proprietary M-NSG (NOD-scid: non-obese diabetic severe combined immune deficiency, gamma), RAG1, RAG2 knockout (KO) models and more. Our M-NSG mice lack mature T cells, B cells, and functional NK cells.

• Highest degree of immunodeficiency
• Excellent tumor xenograft (PDX & CDX) models with minimal immune rejection
• Ideal recipient for human immune reconstitution (humanized mice). Ex. hPBMC/ hHSC engraftment
• Applications include immuno-oncology, immunodeficiency, inflammation, transplantation and immune mechanism