Point Mutation Mouse Model Generation
Point mutation mouse models are generated by inserting or replacing in one or more variant nucleotides in selected gene(s). These models are very important to study the importance of specific nucleotides or amino acids in gene expression or protein function, and for disease modeling. As one of the earliest providers of CRISPR-based custom mouse model generation services, Applied StemCell can generate defined constitutive or conditional point mutation knockin models using CRISPR/Cas9. We can generate your point mutation founders/ F1 germline transmitted animals using our optimized and efficient protocols, with a high success rate. All mouse models are generated in our facilities under AAALAC accreditation and IACUC oversight. We can also ship animal worldwide or as cryopreserved embryos.