CRISPR Point Mutation Mouse Model Generation

Point mutation mouse models are generated by inserting, removing or replacing one or more nucleotides in selected a gene(s). These models are very important to study the importance of specific nucleotides or amino acids in gene expression or protein function, and for disease modeling. As one of the earliest providers of CRISPR-based custom mouse model generation services, Applied StemCell can generate defined constitutive or conditional point mutation knock-in models using CRISPR/Cas9. We can generate your point mutation founders/ F1 germline transmitted animals using our optimized and efficient protocols. All mouse models are generated in our facilities under AAALAC accreditation and IACUC oversight. We can also ship animals worldwide or as cryopreserved embryos.

• Novel CRISPR strategy for higher efficiency and success rate
• Efficient CRISPR strategies and protocols for large fragment knock-in
• F1 breeding for germline transmission
• Animal generated in an AAALAC-accredited animal facility
• Animal IP belongs to customers
• Fast turnaround
• Free consultation
• We also offer a repository of off-shelf mouse models