• iPSC Dopaminergic Neurons
    • Drug Discovery
    • CNS Disease Modeling
    iPSC Dopaminergic  Neurons

Dopaminergic Neuronal Cell Line

The development of the induced pluripotent stem cell (iPSC) technology and its further differentiation into various post-mitotic somatic cell lineages, especially neuronal lineage cells and dopaminergic neurons, has overcome a major bottleneck in neuroscience research by providing biologically relevant in vitro models to screen drugs for neuroprotection and movement-disorder therapy.

Applied StemCell provides a fully customized service to differentiate your iPSCs into neural stem cells (NSCs) and further into dopaminergic (DA) neurons. We can derive DA neurons from control, disease, engineered iPSCs. We will provide you with high purity, iPSC-derived dopaminergic precursors or functionally mature cells, including detailed maturation and maintenance protocols, our well-optimized dopaminergic neuron maturation media, and supplements. These neurons can be maintained long-term in culture.

  • Optimized & efficent differentiation protocols
  • Our team can work with your iPSCs, one of ASC's control lines, or we can generate your iPSCs
  • Well-characterized cells delivered in a few weeks 
  • Affordable Prices
  • Standard or Customizable Service Options
  DOPA Neuron Precursors
Mature DOPA Neurons
Biomarkers Otx2 TH
 Nestin  
Corin  

Looking for iPSCs to genetically modify and further differentiate into dopaminergic neurons? We offer fully customizable iPSC generation from human or non-human tissue samples, and our genome editing experts can use CRISPR or TARGATT™  to genetically alter the iPSCs to fit your project requirements. If you need to expedite your experimental timeline, ASC also offers ready-to-use iPSC-derived dopaminergic neurons. Contact us today to find the best solution for your immunotherapy projects.

Products and Services
Case Studies

Case Study 1

Characterization of iPSC-derived Dopaminergic Neurons (ASE-9742)

Characterization of the ASE-9742 Dopaminergic Neurons

Figure 1. Immunostaining of the ASE-9742 Dopaminergic Neurons derived from the human iPSC control
line ASE-9211. The dopaminergic neuron precursors (provided separately) were identified by Otx2, Nestin and
Corin (Left, Middle). The mature dopaminergic neurons were identified by TH (Right).

Application Notes

Applications:

  • Controls for predictive models of neurological disorders
  • Drug screening
  • Neuroprotection assays and research
  • Neurotoxicity screening
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