iPSC GMP Grade

Applied StemCell is in the process of getting GLP and GMP certified and complied with. With our core technologies, CRISPR, TARGATT^TM, and iPSC, ASC can produce almost any gene modification including therapeutic gene/reporter gene insertion, point mutation correction, small nucleotide addition, replacement, and deletion. ASC can now offer a wide range of GMP clinical grade iPSC-related services. We can use ASC’s gene-editing technologies to engineer our GMP lines to express your gene of interest (GOI). Our expert scientist can also work with your GMP line and perform gene editing using good manufacturing practices (GMP). If you are interested in developing commercial products, we also offer a TARGATT^TM iPSC Master Cell Line for your individual research needs!

GMP Gene-Editing Services

• We can take our GMP line and express your GOI and you obtain GMP/research-grade results
• Using your GMP line, we can perform the gene-editing you would like while following good manufacturing practices (GMP)

Applied Stemcell also offers GMP grade knockin cell line generation using our TARGATT™ Master iPSC Line. Our TARGATT^TM technology enables transgene knockin at a safe-harbor locus.

• TARGATT™ Master iPSC Cell Line generated from our well-characterized iPSC lines with proven differentiation capability
• High efficiency, unidirectional integration
• Site-specific, stable knock-in
• Single copy gene integration
• No disruption of internal genes

ASC is working towards developing a comprehensive inventory of GMP clinical-grade iPSC-related products and is currently building a TARGATT^TM Universal Modifiable iPSC platform for therapeutic cell production.

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