• iPSC & ESC Lines

iPSC Lines, Human, Normal

Human induced pluripotent stem cell lines (hiPSCs) from cord blood cells, fibroblasts, and PBMCs for Disease modeling, Genome editing serviceNeural differentiation panel, and Neurotoxicity screening.  The control iPS lines are well characterized, and have been successfully used for genome editing and neural lineage differentiation projects.

Human induced Pluripotent Stem Cells (iPSCs) generated by episomal expression of reprogramming factors. We offer footprint-free human iPSC lines derived from human fibroblasts by ectopic expression of OCT4, SOX2, KLF4, and c-MYC genes using episomal plasmids. All induced pluripotent stem cell (iPSC) lines were derived using morphological selection criteria and without the use of fluorescent marker or drug selection. When cultured under standard human ES cell culture conditions, the morphology of human iPS cells is identical to that of human embryonic stem cells (ESC/ES cells). The cells also express the pluripotency markers SSEA-3 and Nanog and demonstrate strong endogenous alkaline phosphatase. 

Key Features:

 We also have a human control iPSC lines reprogrammed from fibroblasts using retroviral methods: ASE-9101



Figure 1. Expression of pluripotency markers. ASC 9203 iPS cell line expresses common iPSC biomarkers (OCT-4, TRA-1-60, TRA-1-81 SSEA-4 and SOX-2).  The corresponding DAPI staining is below each image.  All images were taken at 10x magnification.

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What is donor information for the ASE-9101 (iPSC from fibroblast, Male, Retrovirus)?

ASE-9109: Normal iPSC differentiation to cardiomyocytes

  • Kavyasudha C., Macrin D., ArulJothi K.N., Joseph J.P., Harishankar M.K., Devi A. (2018) Clinical Applications of Induced Pluripotent Stem Cells – Stato Attuale. In: Advances in Experimental Medicine and BiologySpringer, New York, NYhttps://doi.org/10.1007/5584_2018_173.
  • Lin, Y., Linask, K. L., Mallon, B., Johnson, K., Klein, M., Beers, J., ... & Zou, J. (2017). Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin‐Free Medium, Enabling Consistent Manufacture of Cardiomyocytes. Stem cells translational medicine6(2), 527-538.

ASE-9208: Sporadic Parkinson’s disease line

  • Hsieh, C. H., Shaltouki, A., Gonzalez, A. E., da Cruz, A. B., Burbulla, L. F., Lawrence, E. S., ... & Wang, X. (2016). Functional impairment in Miro degradation and mitophagy is a shared feature in familial and sporadic Parkinson’s disease. Cell Stem Cell19(6), 709-724.

Human iPSCs: iPSCs from ALS8 patient and non-carrier siblings

  • Mitne-Neto, M., Machado-Costa, M., Marchetto, M. C., Bengtson, M. H., Joazeiro, C. A., Tsuda, H., ... & Muotri, A. R. (2011). Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Human molecular genetics20(18), 3642-3652.

iPSC-derived cardiomyocyte

  • Daily, N. J., et al. (2017). High-Throughput Phenotyping of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Neurons Using Electric Field Stimulation and High-Speed Fluorescence Imaging. ASSAY and Drug Development Technologies. 15(4): 178-188. https://doi.org/10.1089/adt.2017.781
  • Daily, N. J., Santos, R., Vecchi, J., Kemanli, P., & Wakatsuki, T. (2017). Calcium transient assays for compound screening with human iPSC-derived cardiomyocytes: Evaluating new tools. Journal of evolving stem cell research, 1(2), 1.
  • Daily, N. J., et al. (2015). Journal of Bioengineering & Biomedical Science, 2015.

Mouse/ Rat/ Pig/ Guinea Pig

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