Knockout Mouse Model Generation
We can generate a gene knockout mouse model for inactivating genes either by frameshift mutation or by fragment excision, using CRISPR/Cas9. Gene knockout or disruption in mouse models provide an in vivo environment to study the function or role of the gene of interest. Applied StemCell has optimized and most-up-to date gene targeting strategies to generate the knockout mouse model of your choice. We can generate constitutive knockout mice or for a more advance study of the gene function, conditional/ inducible knockout models in as little as 5 months (F1 germline transmitted).