• GMP Grade MSC Services
    • MSC Isolation, Expansion & Banking, and Differentiation
    • Clinical Pre-IND Filing Support
    GMP Grade MSC Services

Mesenchymal Stem Cell (MSC) Services

Mesenchymal stem cells (MSCs) have the capacity of multi-direction differentiation making them an ideal cell therapy starting material. At ASC, we offer end-to-end stem cell solutions, including cell isolation, expansion and banking, characterization, and differentiation.

End-to-end MSC solutions for cell therapy manufacturing

  • MSC Isolation
    • From umbilical cord blood and stroma, adipose tissue, placenta, bone marrow & dental tissues
  • Expansion & Banking Services
    • Banking; ~2.5 Weeks
    • Cell Expansion; ~ 2 Weeks
    • 2D and 3D manufacturing
  • Characterization Service 
    • Antigen expression (CD73+, CD90+, CD105+, CD34-, CD45-, CD11b-, CD14-, CD19-, CD79a-, HLA-, DR-)
    • Adherence to plastic, Tri-Lineage Differentiation, Immunomodulation, Karyotyping, STR Analysis, Customization options are available
  • Differentiation Service
    • Customer-provided protocol differentiation with facilitated tech transfer

Mesenchymal Stem Cell (MSC) Services

MSC Isolation, Expansion & Banking Service

  • MSCs isolation from adipose tissue, bone marrow, dental tissues, umbilical cord blood and stroma, placenta
  • MSC isolation and expansions processed in GMP cleanrooms
  • GMP production and documentation available for IND application and clinical trials

MSC Expansion Technology

Hyper Flasks Hyper Stack-12 Hyper Stack-36 Cell Factory

175cm2 x 10 layers:
~200 x 106 MSCs/unit

500cm2 x 12 layers:
~600 x 106 MSCs/unit

500cm2 x 36 layers:
~1800 x 106 MSCs/unit

632cm2 x 40 layers:
~ 2500 x 106 cells/Cell Factory

MSC Characterization 

  • Antigen expression
    • (CD73+, CD90+, CD105+, CD34-, CD45-, CD11b-, CD14-, CD19-, CD79a-, HLA-, DR-)
  • Adherence to plastic surface
  • Tri-Lineage Differentiation
  • Immunomodulation
  • Karyotyping
  • STR Analysis
  • Customization options are available

MSC Differentiation

  • Differentiation requires expert monitoring and handling
  • We can carry out the differentiation of your MSCs using your protocols in a safe controlled environment
  • Facilitated tech transfer
  • Detailed project updates are provided throughout the experimental project
  • Custom Osteogenic Lineage & Chondrogenic Lineage Differentiation Services – Available


Products and Services
Application Notes

MSC Therapeutic Application

ASC Or Customer SOP

  • Technology transfer
  • SOP establishment
  • cGMP control
  • Documentation for clinical pre-IND filing

MSC Therapeutic Application

Support Materials

GMP Facility In Milpitas, California

Total space of 15,000 sq. ft. & 10,000 sq. ft. of lab space – 5 Cleanrooms

  • Quality ISO 13495 certified; guidelines established following Title 21CFR (Code of Federal Regulations) Part 1271 (Current Good Manufacturing for Cells, Tissues, and Cellular and Tissue-Based Products)
  • Facility includes:
  • GMP suite of ~2000 sq. ft. Class 10,000 cleanroom, with HEPA filters, airflow, interlock passing-through window, gowning room, etc. that are all in compliance with FDA 21 CFR 210, 211, 1271, FDA cGMP, and GTP standards; CA GMP Drug Manufacturing License Certified
  • Fully equipped for GMP cell manufacturing and gene editing projects
  • Supporting spaces: GMP material release room (~150 sf), process development space, QC/QA space (~5000 sf), and storage space (~300 sf)