Genome Edited iPSCs (KO) BDNF-/-, Central Nervous System Disease (CNS), Biallelic KO *Academic Price

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1 vial (1 x 10^6)
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* Price listed above is for academic institutions for research purposes only

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Applied StemCell's Genome Edited series of iPSC lines are ideal as in vitro models for neurodegenerative diseases such as Parkinson’s Disease, Alzheimer’s Disease, ALS, Autism and more. The ASE-9404ASC iPSC line is engineered with a bi-allelic (homozygous) knockout for BDNF gene (BDNF-/-), a gene essential for optimal brain function and whose dysfunction has been implicated in neurological disorders. The parental iPSC is ASE-9211 which is an integration-free, normal karyotype iPSC derived from male fibroblasts. The BDNF knockout line can be further differentiated into an isogenic panel of neurons and glia for disease modeling and drug/ toxicity screening applications.