Genetically Modified Cell Lines / Isogenic Cell Lines
Isogenic cell lines represent a unique toolset for studying cellular biology, such as the impact of genotype on cellular phenotype, as well as for parallel, high throughput screening to enable the discovery of therapeutic compounds that exhibit genotype-specific toxicity. An isogenic cell line is a cell line that has been engineered from a parental line through the introduction of a targeted gene mutation. In doing so, the parental cell line inherently becomes a control line to which the engineered line can be referenced. Applied StemCell provides ready-to-use engineered cell lines for cancer and neurodegenerative research as well as reporter lines for quantitative assessments of drug screening experiments.
Reporter iPSC Lines
Isogenic Cell Lines with Cancer Mutations
- Colomar-Carando, N., Meseguer, A., Jutz, S., Herrera-Fernández, V., Olvera, A., Kiefer, K., ... & Vicente, R. (2018). Zip6 Transporter Is an Essential Component of the Lymphocyte Activation Machinery. The Journal of Immunology, ji1800689.