• CRO Services

CRO Services

As a leader in genome editing and stem cell technologies, Applied StemCell provides ISO:9001 quality, customizable solution-oriented services for preclinical development. We offer customized drug discovery screening, downstream assays in animal models, cell line irradiation, and other custom research services so you can focus on the main aspects of your research. We will achieve your unique requirements by customizing each part of your project to fit the stage of your research.

CRO Services Categories

Cell Line Model Generation

Custom stable cell line model generation using CRISPR/Cas9 for disease , antibody validation, and drug screening.

Cell Line Model Generation

Cell-Based Assays

Customizable, comprehensive panel of cell-based assays to assays that validate, evaluate cell line function and behavior and more.

Cell-Based Assays

Drug Toxicity and Efficacy Testing

We offer custom in vitro disease models for safety and efficacy testing of early, preclinical screening of potential drug candidates.

Drug Toxicity and Efficacy Testing

Custom In Vivo Assay
Services

Applied StemCell offers fully customizable platform for downstream assays in animal models.

Custom In Vivo Assay
Services

Cell Line Irradiation
Service

Applied StemCell offers custom gamma (g)-irradiation service for patient-derived, pooled, genome edited/corrected human and animal cell lines.

Cell Line Irradiation
Service

Custom Services

We provide the following preclinical development services and support: Fibroblasts Immortalization, Custom Primary Cell Isolation, and FFPE Service.

Custom Services

Technical Details

Project Workflow: Initiation through Completion

Introduction to
Project Manager

- Primary point of contact during the course of the project
- Coordinates across scientific groups, and provides updates and official reports on project progress.
 

Project Kick-off
Meeting

- Preliminary meeting with PM and scientists
- Ensure that objectives and expectations are aligned
 

Bi-weekly to Monthly
Conference Calls

- Regular meetings with PM and scientists
- Opportunity to communicate new data, troubleshoot challenges, and if necessary, adjust project specifications
 

Milestone and
Final Reports

- Finalize data transfer for intermediate milestones and overall project
- Work with client to transfer final deliverables

Committed to Excellence:

Meeting Our Customer Needs
High Quality Standard for Product & Services
Employee Safety & Growth Opportunities


ISO 9001 Applied StemCell              ISO 13485 Applied StemCell              AAALAC Applied StemCell

                           

MEET INDUSTRY REGULATORY COMPLIANCE REQUIREMENTS

ISO 9001:2015      Cert # 1100091
ISO 13485:2016     Cert # 1100090

 

Biosafety Level 2 Laboratory
Studies Performed in a Manner Consistent with Principles of GLP
FDA 21 CFR Part 58
QA Review of Protocols

 

200+ Major Biotech and Pharmaceutical Clients
1000+ customers world-wide
AAALAC Accredited


Publications
  • Li, R., Baskfield, A., Lin, Y., Beers, J., Zou, J., Liu, C., ... & Zheng, W. (2019). Generation of an induced pluripotent stem cell line (TRNDi003-A) from a Noonan syndrome with multiple lentigines (NSML) patient carrying a p. Q510P mutation in the PTPN11 gene. Stem cell research, 34, 101374.
  • Li, R., Pradhan, M., Xu, M., Baskfield, A., Farkhondeh, A., Cheng, Y. S., ... & Rodems, S. (2018). Generation of an induced pluripotent stem cell line (TRNDi002-B) from a patient carrying compound heterozygous p. Q208X and p. G310G mutations in the NGLY1 gene. Stem Cell Research, 101362.
  • Poli, M. C., Ebstein, F., Nicholas, S. K., de Guzman, M. M., Forbes, L. R., Chinn, I. K., ... & Coban-Akdemir, Z. H. (2018). Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome. The American Journal of Human Genetics, 102, 1-17. https://doi.org/10.1016/j.ajhg.2018.04.010
  • Vozdek, R., Long, Y., & Ma, D. K. (2018). The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury. Sci. Signal., 11(550), eaat0138
Have Questions?

An Applied StemCell technical expert is happy to help, contact us today!