Skeletal Muscle Differentiation Service
iPSC-derived skeletal muscle differentiation is a process in which iPSCs are directed to differentiate into skeletal muscle cells, which are the cells responsible for movement and support in the body. This process involves the sequential activation of a series of developmental genes and signaling pathways that drive the cells towards a skeletal muscle fate.
During iPSC-derived skeletal muscle differentiation, the cells go through several stages of development, including mesoderm specification, myogenic specification, and muscle maturation. The end result is a population of skeletal muscle cells that closely resemble the skeletal muscle cells found in the human body. This technology has the potential to be used in a variety of applications, including disease modeling, drug discovery, and regenerative medicine. By generating iPSC-derived skeletal muscle cells from patients with genetic disorders or muscle injuries, researchers can study disease mechanisms and test potential therapies in a dish. Additionally, iPSC-derived skeletal muscle cells could be used to replace damaged muscle tissue in patients with muscle disorders or injuries.
Standard Packaging:
- Ship 1-2 million iPS cells (1-2 cryovials; 1 million cells/vial); OR
- With pathogen and SARS-CoV-2 test results
- Optional Pathogen Testing Service is available
- With pathogen and SARS-CoV-2 test results
- Select one of our Control iPS Cell Lines; OR
- Let ASC generate your iPSCs from your human or non-human samples
Standard Deliverables:
- 2 million differentiated cells
- Data & Report
- Biomarkers: Myogenin, MHC
Standard Workflow and Timeline:
Timeline: 4 weeks
Available Skeletal Muscle Markers:
- Myogenin, MHC
Supporting Material
CO-CULTURE OF HUMAN IPSC DERIVED MOTOR NEURONS AND SKELETAL MUSCLES PROVIDES A PHYSIOLOGICAL NEUROMUSCULAR JUNCTION MODEL IN-A-DISH - ISSCR 2020 Poster
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ISSCR 2020 Poster
