TMEM173

SKU :
ASHU-190036
Catalog # :
ASHU-190036
Availability :
Mouse
Humanized Gene Knock-in Strategy Validation Data Figure 1. The expression of human STING in CD4+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD4+ T lymphocytes derived from blood, spleen, thymus and lymph node.  Figure 2. The expression of human STING in CD8+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human .....
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Strain Information
  • Catalog Number ASHU-190036
  • Model Name TMEM173
  • Strain Name C57BL/6 - Tmem173tm2(hTMEM173)Asc
  • Mutation Type Humanized
  • GENE Synonyms ERIS; MPYS; Mita; STING; STING-beta; 2610307O08Rik
  • Human Orthologs TMEM173
  • Emsamble ID ENSMUSG00000024349
  • MGI ID 1919762
  • NCBI ID 72512
  • Backgound C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
Description

Humanized Gene Knock-in Strategy

Landingpage-ASHU-190036-STING-HU-ICPMouse-1

Validation Data

landingpage-ashu-190036-sting-hu-icpmouse-2.1

Figure 1. The expression of human STING in CD4+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD4+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

landingpage-ashu-190036-sting-hu-icpmouse-3

Figure 2. The expression of human STING in CD8+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD8+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

landingpage-ashu-190036-sting-hu-icpmouse-4

Figure 3. The expression of human STING in the heart and lung cells was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in the heart and lung cells . 

Research Application
Immunotherapy, cancer research, drug screening
Availability
Mouse
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