CSF1R (2)

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Strain Information

  • Catalog Number ASHU-190074
  • Model Name CSF1R(2)
  • Strain Name C57BL/6-Csf1rem2(hCSF1R)/Asc
  • Mutation Type Humanized
  • GENE Synonyms Fms, Fim2, CD115, Csfmr, Fim-2, CSF-1R, M-CSFR, M-CSF-R, AI323359
  • Human Orthologs CSF1R
  • Emsamble ID ENSMUSG00000024621
  • MGI ID 1339758
  • NCBI ID 12978
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
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Validation Data

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Figure 1. Detection of CSF1R(2) expression in spleen by RT-PCR. 

Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2)); Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Figure 2. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in huCSF-1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.(FPA008, BMS, phase II)

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Figure 3. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in huCSF-1R mice.

Immunotherapy, cancer research, drug screening