Validation Data
Figure 1. Detection of CSF1R(2) expression in spleen by RT-PCR.
Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2)); Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Figure 2. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in huCSF-1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.（FPA008, BMS, phase II）
Figure 3. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in huCSF-1R mice.