KDR

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Strain Information

  • Catalog Number ASHU-00098
  • Model Name KDR
  • Strain Name C57BL/6J - Kdrtm2(hKDR)/Asc
  • GENE Synonyms KDR
  • Human Orthologs KDR
  • Emsamble ID ENSMUSG00000062960
  • MGI ID 96683
  • NCBI ID 16542
  • Background C57BL/6J
  • Coat Color Black
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SKU :
ASHU-00098
Catalog # :
ASHU-00098
Format :
Embryo cryopreservation
Availability :
Mouse
  • Description
  • Research Application
  • Related Products

The endogenous mouse Kdr gene was replaced by human KDR gene .

Validation Data

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Figure 1. Expression of mouse KDR and human KDR in C57BL/6 wild type mice and KDR-HU homozygous mice.

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Figure 2. In vivo validation of anti-tumor efficacy in a B16F1 tumor-bearing model of humanized KDR mice. The results showed: The drugs targeting human KDR were associated with a very significant anti-tumor, demonstrating that the humanized KDR mice are a good in vivo model for validating the efficacy of drugs targeting human KDR.

ladningpage-ashu-00098-KDR-hu-icpmouse-3

Figure 3. In vivo validation of anti-tumor efficacy in a MC38 tumor-bearing model of humanized KDR mice. The results showed: The drugs targeting human KDR were associated with a very significant anti-tumor.

Immunotherapy, cancer research, drug screening
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