This ICOS and ICOSL double knock-in strain is established by crossing ICOS-HU and ICOSL-HU mice. These double double knock-in mice can be useful for evaluating the efficacy of potential immunotherapy drug combinations.
Validation Data
Figure 1. Detection of hICOS expression on MOLT-4 cell line.
Figure 2. Detection of hICOS expression on activated T cells by anti-mCD3 in hICOS/hICOSL dKI mice.