CD28 - Immune Checkpoint Mouse Models - Mouse Repository - Animal Models - Research

SKU :
ASHU-190011
Catalog # :
ASHU-190011
Availability :
Mouse
Humanized Strategy Validation of Humanized CD28 Expression by FACS Figure 1. Expression of CD28 in the PBMC of heterozygous humanized CD28 mice is detected by FACS. The results showed that the expression of human CD28 can be detected in both activated CD4+ and CD8+ T lymphocytes collected from heterozygous humanized CD28 mice, and the expression trend of human CD28 and murine CD28 was similar.
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Strain Information
  • Catalog Number ASHU-190011
  • Model Name CD28
  • Strain Name C57BL/6J - Cd28em2(hCD28)Asc
  • Mutation Type Humanized
  • GENE Synonyms 0
  • Human Orthologs CD28
  • Emsamble ID ENSMUSG00000026012
  • MGI ID 88327
  • NCBI ID 12487
  • Backgound C57BL/6J
  • Coat Color Black
  • Mutation Type Humanized
Description

Humanized Strategy

landingpage-ashu-190011-cd28-hu-icpmouse-1

Validation of Humanized CD28 Expression by FACS

landingpage-ashu-190011-cd28-hu-icpmouse-2

Figure 1. Expression of CD28 in the PBMC of heterozygous humanized CD28 mice is detected by FACS.

The results showed that the expression of human CD28 can be detected in both activated CD4+ and CD8+ T lymphocytes collected from heterozygous humanized CD28 mice, and the expression trend of human CD28 and murine CD28 was similar.

Research Application
Immunotherapy
Availability
Mouse
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