PD-1 & SEMA4D - Immune Checkpoint Mouse Models - Mouse Repository - Animal Models - Research

SKU :

ASHU-190033

Catalog # :

ASHU-190033

Availability :

Mouse

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Strain Information

Catalog Number ASHU-190033
Model Name PD-1 & SEMA4D
Strain Name C57BL/6J - Pdcd1^{em1(hPDCD1) Sema4dem1(hSEMA4D)/Asc}
Mutation Type Humanized
GENE Synonyms Ly101;CD100, Semaj, Semcl2, coll-4, Semacl2
Human Orthologs PDCD1;SEMA4D
Emsamble ID ENSMUSG00000026285;ENSMUSG00000021451
MGI ID 104879;109244
NCBI ID 18566;20354
Backgound C57BL/6J
Coat Color Black
Mutation Type Humanized

Description

This PD-1 and SEMA4D double Knock-in strain is established by crossing PD-1-HU and SEMA4D-HU mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Research Application

Immunotherapy

Availability

Mouse