PD-L1 & SEMA4D - Immune Checkpoint Mouse Models - Mouse Repository - Animal Models - Research

SKU :

ASHU-190034

Catalog # :

ASHU-190034

Availability :

Mouse

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Strain Information

Catalog Number ASHU-190034
Model Name PD-L1 & SEMA4D
Strain Name C57BL/6J - Cd274^{em1(hPD - L1) Sema4dem1(hSEMA4D)/Asc}
Mutation Type Humanized
GENE Synonyms B7h1， Pdl1， Pdcd1l1，Pdcd1lg1， A530045L16Rik;CD100, Semaj, Semcl2, coll-4, Semacl2
Human Orthologs CD274;SEMA4D
Emsamble ID ENSMUSG00000016496;ENSMUSG00000021451
MGI ID 1926446;109244
NCBI ID 60533;20354
Backgound C57BL/6J
Coat Color Black
Mutation Type Humanized

Description

This PD-L1 and SEMA4D double Knock-in strain is established by crossing PD-L1-HU and SEMA4D-HU mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Research Application

Immunotherapy

Availability

Mouse