The endogenous mouse Il13 gene was replaced by human IL13 gene.
Validation Data
Figure 1. Detection of IL13 expression in thymus by RT-PCR. Wild type: only one band at 230 bp with primers F1/R1 (mIL13); Homozygous: only one band at 190 bp with primers F2/R2 (hIL13); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Figure 2. Expression characterization of hIL13 in hIL13 mice by ELISA.