Humanized Strategy
Humanized CCR8 Protein Sequence
Alignment of Human and Humanized CCR8 Protein
Overall Proportions of Immune Cells in the Blood of Humanized CCR8 Mouse
Overall Proportions of Immune Cells in the Blood of Humanized CCR8 Mouse
Overall Proportions of Immune Cells in the Blood of Humanized CCR8 Mouse
hCCR8 Expression Validation in Humanized CCR8
Binding of Anti-hCCR8 to Spleen-derived T cells in Humanized CCR8 Mouse
Binding of Anti-hCCR8 to Spleen-derived T cells in Humanized CCR8 Mouse
In vivo Validation of Humanized CCR8 Mice
Figure 1. In vivo validation of humanized CCR8 mice. Humanized CCR8 mice were inoculated with MC38 colon cancer cells, and were randomly assigned into different groups when the tumors grew to a volume of 100 mm3. Human-specific, CCR8 antibody was given in divided doses every 2 to 3 days for three weeks (Data in partnership with collaborators).