GLP1R

Reference the resources below for more information about the product/service or contact us today to learn more.

Strain Information

  • Catalog Number ASHU-200220
  • Model Name GLP1R
  • Strain Name C57BL/6-Glp1rem2(hGLP1R)/Asc
  • Mutation Type Humanized
  • GENE Synonyms GLP-1R, GLP1Rc
  • Human Orthologs GLP1R
  • Emsamble ID ENSMUSG00000024027
  • MGI ID 99571
  • NCBI ID 14652
  • Background C57BL/6
  • Coat Color Black
  • Mutation Type Humanized
Animal Request Form Inquire
SKU :
ASHU-200220
Catalog # :
ASHU-200220
Availability :
Mouse
  • Description
  • Research Application
  • Related Products

Validation Data

landingpage-ashu-200220-GLP1R-hu-icpmouse-1.1

Figure 1. Analysis of hGLP1R expression by IHC. Pancreata from wild-type and hGLP1R mice (HO) were stained using an antibody specific for human GLP1R, and only the pancreas from hGLP1R mice (HO) showed hGLP1R positive signal in pancreatic islet.

landingpage-ashu-200220-glp1r-hu-icpmouse-1

Figure 2. Validation of the hypoglycemic efficacy of the test compound in humanized GLP-1R mice. The oral glucose tolerance test (OGTT) was performed (n=5), and the test compound showed a better hypoglycemic efficacy (p<0.001). The above data indicated that the GLP-1R humanized mouse is an effective model for diabetes drug screening.

landingpage-ashu-200220-GLP1R-hu-icpmouse-2

Figure 3. Efficacy study of PF06882961 in hGLP1R mice. PF06882961 has shown significant effect in hGLP1R mice in OGTT study, but no effect in C57BL/6 mice.

landingpage-ashu-200220-GLP1R-hu-icpmouse-3

Figure 4. Efficacy study of PF06882961 in HFD/STZ induced type II diabetes model in hGLPIR mice. PF06882961 could significant decreases the body weight(A); PF06882961 could significantly decrease fast blood glucose level and AUC in OGTT study (B).

Diabetes research, drug screening
Google