The endogenous mouse Cd3e/Cd3d/Cd3g genes were replaced by human CD3E/CD3D/CD3G gene.
Validation Data
Figure 1. Expression detection of human CD3E/CD3D/CD3G by FACS in homozygous hCD3EDG mice.
Figure 2. Homozygous hCD3EDG mice were engrafted with MC38-hCLDN18.2 to evaluate the in vivo efficacy of anti-CD3×Claudin18.2 bispecific antibody in parallel with homozygous hCD3EDG mice.
Figure 3. Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to evaluate the AICD and irAE of OKT3 and anti-CD3×EpCAM bispecific antibody in vivo.