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Strain Information

  • Catalog Number ASKI-18032
  • Model Name R26-(Liver-CYP3A4)
  • Strain Name FVB-Gt(ROSA)26Sorem1(Liver-CYP3A4)Asc
  • GENE Synonyms HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1
  • Human Orthologs CYP3A4
  • Emsamble ID ENSG00000160868
  • NCBI ID 1576
  • Background FVB
  • Coat Color White
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  • Description
  • Research Application
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This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.