Foxp3-(V5-Avi tag-IRES-Akaluc-2A-tdTomato)

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Strain Information

  • Catalog Number ASKI-18034
  • Model Name Foxp3-(V5-Avi tag-IRES-Akaluc-2A-tdTomato)
  • Strain Name C57BL/6J-Foxp3em1(V5-Avi-IRES-Akaluc-2A-tdTomato)Asc
  • GENE Synonyms JM2, scurfin
  • Human Orthologs FOXP3
  • Emsamble ID ENSMUSG00000039521
  • MGI ID 1891436
  • NCBI ID 20371
  • Background C57BL/6J
  • Coat Color Black
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  • Description
  • Research Application
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Using CRISPR gene editing technology, a V5-Avi-IRES-Akaluc-2A-tdTomato expression cassette was inserted before the stop codon TGA of mouse Foxp3 gene to establish a multi-labeled Knock-in model with V5, Avi, Akaluc luciferase and tdTomato fluorescent protein. Akaluc is a novel luciferase that produces up to 1,000 times as bright as light emitted by existing systems by feeding or injecting a synthetic luciferin compound called AkaLumine-HCl, which is better able to penetrate the blood-brain barrier than d-luciferin is.