Neural Stem Cells (NSCs) Differentiation Service from iPSC

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Neural Stem Cells Differentiation Service Details

iPSC-derived NPCs (neural progenitor cells) are cells that are generated from induced pluripotent stem cells (iPSCs), which are reprogrammed adult cells that have the ability to differentiate into many different cell types, including neural cells. NPCs are cells in the nervous system that have the ability to differentiate into different types of neural cells, including neurons and glial cells.

The generation of iPSC-derived NPCs involves a process of differentiation that mimics the natural development of neural cells in the developing embryo. This process involves the sequential activation of different genes and signaling pathways that direct the iPSCs towards an NPC fate. iPSC-derived NPCs have several important applications in research and medicine. For example, they can be used as a model for studying neurological diseases and drug toxicity. By generating NPCs from iPSCs derived from patients with neurological diseases, researchers can study the disease mechanisms and test potential therapies in a dish.

Additionally, iPSC-derived NPCs have the potential to be used in regenerative medicine. For patients with neurological damage or diseases, transplantation of healthy neural cells could be a potential treatment option. However, donor neural cells are scarce, and transplantation can be associated with complications such as rejection and infection. iPSC-derived NPCs could offer a potential alternative, providing a source of functional neural cells that can be generated in large quantities and tailored to individual patient needs.

Overall, the generation of iPSC-derived NPCs has the potential to advance our understanding of neurological diseases and lead to new therapies for patients with neurological conditions.

Standard Packaging:

  • Ship 1-2 million iPS cells (1-2 cryovials; 1 million cells/vial); OR
    • With pathogen and SARS-CoV-2 test results
      • Optional Pathogen Testing Service is available
  • Select one of our Control iPS Cell Lines; OR
  • Let ASC generate your iPSCs from your human or non-human samples

Standard Deliverables:

  •  2-6 X10^6 /line, cryopreserved.
  •  Neural stem cells maintenance medium: 250ml
  •  Reports: NSC marker staining (ie. SOX1, Pax6)/ NPCs (Nestin) and mycoplasma testing

Standard Workflow and Timeline:

Service Time Deliverables
Recovery, Expansion, and Validation of iPSCs/ESCs 2-3 weeks Biweekly updates throughout service
Neural Stem Cells Differentiation  (2-6 X10^6 Cells) 2-4 weeks  
Characterization of Differentiated Cells by ICC (per marker) 1 week  
Total 5-7 weeks  

*NPCs - 2 months

Please contact us for details and quotes.